Abstract
This work describes an effective microwave-assisted synthesis of new hybrid regioisomeric molecules N-linked-1,2,3-triazole along with pyranopyrimidinone moiety under copper(I) catalyst, and the evaluation of their anticholinesterase and antibacterial activities. All of the obtained structures have been assigned by means of spectroscopic data (NMR, HRMS). The triazole derivatives 4 showed potent anti-cholinesterase activity such as compound 4a (Ar = Ar1 = Ph; IC50 = 6.7 ± 0.2 μM). Most of 1,2,3-triazoles derivatives 4 were found to be active against Pseudomonas savatanoi. Besides, in silico docking studies were also performed to give rational explanation for their biological activities against BuChE.
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•A series of new 1,2,3-triazole linked pyranopyrimidinones 4a-n was regiospecifically synthesized using microwave irradiation.•The structures of the new hybrid compounds were performed by spectroscopic means.•All compounds were screened in vitro for their antibacterial and anticholinesterase potentialities.•Most of 1,2,3-triazoles derivatives 4 were found to be active against Pseudomonas savatanoi.•Docking studies of some pyranopyrimidinone-1,2,3-triazoles gave rational explanation for their activity against BuChE.