Abstract
Three series of novel pyrazole derivatives
2b–
d,
4a–
d and
6a–
d were synthesized
via two step procedure that utilizes hydrazonoyl chlorides
1a–
d and enaminones
3a–
d and
5a–
d, respectively as starting materials. The structures of all the newly synthesized products have been established on the basis of analytical and spectral data. Moreover, some of the products
2–
6 were tested against HCV and Subacute Sclerosing Panencephalitis (SSPE). In addition, compounds
2–
6 were also tested for the inhibition of peroxynitrite-induced tyrosine nitration and antioxidant activity. The tested compounds are highly effective at very low concentration as anti-HCV, SSPE antioxidant and anticancer in the following ascending order
2d,
4c,
6b,
3b,
6c,
4d,
2b,
2c,
2a,
6a,
5b,
5a,
3a,
4b and
5c. It is worth to mention that all tested compounds are more potent than the reference standards used for comparing activity. All the measurements revealed that the mechanism of action of the anti cancer activities of all the tested compounds is topoisomerase I inhibitor.
[Display omitted]