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New route for the synthesis of N-alkyl-2-(phenylsulfonyl)anilines
Journal article   Peer reviewed

New route for the synthesis of N-alkyl-2-(phenylsulfonyl)anilines

Aisha Hossan
Chemistry of heterocyclic compounds (New York, N.Y. 1965), Vol.52(8), pp.570-573
01/08/2016
DOI: https://doi.org/10.1007/s10593-016-1933-4

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
The main objective of this work was to study the rearrangement reactions of 1-alkyl-2-[(phenylsulfonyl)methyl]pyridinium iodides in the presence of various nucleophiles, leading to N-alkyl-2-(phenylsulfonyl)aniline derivatives. The best results were achieved with alkylammonium sulfites, leading to pyridine ring opening followed by recyclization to give diphenyl sulfone derivatives in up to 78% yields.

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