New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann; Anika Grosshennig; Peter S. Braund; Inke R. Koenig; Christian Hengstenberg; Alistair S. Hall; Patrick Linsel-Nitschke; Sekar Kathiresan; Ben Wright; David-Alexandre Tregouet; Francois Cambien; Petra Bruse; Zouhair Aherrahrou; Arnika K. Wagner; Klaus Stark; Stephen M. Schwartz; Veikko Salomaa; Roberto Elosua; Olle Melander; Benjamin F. Voight; Christopher J. O'Donnell; Leena Peltonen; David S. Siscovick; David Altshuler; Piera Angelica Merlini; Flora Peyvandi; Luisa Bernardinelli; Diego Ardissino; Arne Schillert; Stefan Blankenberg; Tanja Zeller; Philipp Wild; Daniel F. Schwarz; Laurence Tiret; Claire Perret; Stefan Schreiber; Nour Eddine El Mokhtari; Arne Schaefer; Winfried Maerz; Wilfried Renner; Peter Bugert; Harald Klueter; Juergen Schrezenmeir; Diana Rubin; Stephen G. Ball; Anthony J. Balmforth; H-Erich Wichmann; Thomas Meitinger; Marcus Fischer; Christa Meisinger; Jens Baumert; Annette Peters; Willem H. Ouwehand; Panos Deloukas; John R. Thompson; Andreas Ziegler; Nilesh J. Samani; Heribert Schunkert; Italian Atherosclerosis Thrombosis

doi:10.1038/ng.307

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New susceptibility locus for coronary artery disease on chromosome 3q22.3

Journal article

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New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann, Anika Grosshennig, Peter S. Braund, Inke R. Koenig, Christian Hengstenberg, Alistair S. Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David-Alexandre Tregouet, …

Nature genetics, Vol.41(3), pp.280-282

01/03/2009

DOI: https://doi.org/10.1038/ng.307

PMCID: PMC2695543

PMID: 19198612

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in similar to 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

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Title: New susceptibility locus for coronary artery disease on chromosome 3q22.3
Creators - without role: Jeanette Erdmann - University of Lübeck
Anika Grosshennig - University of Lübeck
Peter S. Braund - University of Leicester
Inke R. Koenig - University of Lübeck
Christian Hengstenberg - University of Regensburg
Alistair S. Hall - University of Leeds
Patrick Linsel-Nitschke - University of Lübeck
Sekar Kathiresan - Harvard University
Ben Wright - University of Leicester
David-Alexandre Tregouet - Université Paris Cité
Francois Cambien - Université Paris Cité
Petra Bruse - University of Lübeck
Zouhair Aherrahrou - University of Lübeck
Arnika K. Wagner - University of Lübeck
Klaus Stark - University of Regensburg
Stephen M. Schwartz - University of Washington
Veikko Salomaa - Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis Prevent, Chron Dis Epidemiol Unit, FI-00271 Helsinki, Finland
Roberto Elosua - College Station Medical Center
Olle Melander - Malmö University
Benjamin F. Voight - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Christopher J. O'Donnell - NHLBI, NIH, Bethesda, MD 20824 USA
Leena Peltonen - Wellcome Sanger Institute
David S. Siscovick - University of Washington
David Altshuler - Harvard University
Piera Angelica Merlini - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Flora Peyvandi - University of Milan
Luisa Bernardinelli - University of Pavia
Diego Ardissino - University of Parma
Arne Schillert - University of Lübeck
Stefan Blankenberg - Johannes Gutenberg University Mainz
Tanja Zeller - Johannes Gutenberg Univ Mainz, Dept Med 2, D-55099 Mainz, Germany
Philipp Wild - Johannes Gutenberg University Mainz
Daniel F. Schwarz - University of Lübeck
Laurence Tiret - Université Paris Cité
Claire Perret - Université Paris Cité
Stefan Schreiber - Univ Kiel, Inst Klin Mol Biol, D-24118 Kiel, Germany
Nour Eddine El Mokhtari - Univ Kiel, Inst Klin Mol Biol, D-24118 Kiel, Germany
Arne Schaefer - Univ Kiel, Inst Klin Mol Biol, D-24118 Kiel, Germany
Winfried Maerz - Synlab
Wilfried Renner - University of Graz
Peter Bugert - Univ Heidelberg, Inst Transfus Med & Immunol, D-69117 Heidelberg, Germany
Harald Klueter - Univ Heidelberg, Inst Transfus Med & Immunol, D-69117 Heidelberg, Germany
Juergen Schrezenmeir - Inst Physiol & Biochem Ernahrung, Bundesforsch Sanstalt Ernahrung & Lebensmittel, D-24118 Kiel, Germany
Diana Rubin - Inst Physiol & Biochem Ernahrung, Bundesforsch Sanstalt Ernahrung & Lebensmittel, D-24118 Kiel, Germany
Stephen G. Ball - University of Leeds
Anthony J. Balmforth - University of Leeds
H-Erich Wichmann - Helmholtz Zentrum München
Thomas Meitinger - Helmholtz Zentrum München
Marcus Fischer - University of Regensburg
Christa Meisinger - Helmholtz Zentrum München
Jens Baumert - Helmholtz Zentrum München
Annette Peters - Helmholtz Zentrum München
Willem H. Ouwehand - University of Cambridge
Panos Deloukas - Wellcome Sanger Institute
John R. Thompson - University of Leicester
Andreas Ziegler - University of Lübeck
Nilesh J. Samani - University of Leicester
Heribert Schunkert - University of Lübeck
Italian Atherosclerosis Thrombosis
Publication Details: Nature genetics, Vol.41(3), pp.280-282
Publisher: Springer Nature
Number of pages: 3
Grant note: U54 RR020278; U54RR020278 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01HL087676 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01 HL056931-02; R01 HL056931-03; R01HL087676; R01 HL056931-04; R01 HL087676 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) British Heart Foundation 077011; 089061; 076113 / Wellcome Trust; European Commission Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission U54RR020278 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
Identifiers: 9938146308331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article