Abstract
A new total synthesis in five steps of the alkaloid Orelline is reported. The methodology involves metalation of methoxypyridines to afford 2-halo-3,4-dimethoxypyridine on which an homocoupling reaction is performed to build the 2,2′-bipyridyl structure of the alkaloid.
A new total synthesis in five steps of the alkaloid Orelline is reported. The methodology involves metalation of methoxypyridines to afford 2-halo-3,4-dimethoxypyridine on which an homocoupling reaction is performed to build the 2,2′-bipyridyl structure of the alkaloid.