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Nickel-Catalyzed Synthesis of Primary Aryl and Heteroaryl Amines via C-O Bond Cleavage
Journal article   Peer reviewed

Nickel-Catalyzed Synthesis of Primary Aryl and Heteroaryl Amines via C-O Bond Cleavage

Huifeng Yue, Lin Guo, Xiangqian Liu and Magnus Rueping
Organic letters, Vol.19(7), pp.1788-1791
07/04/2017
DOI: https://doi.org/10.1021/acs.orglett.7b00556
PMID: 28287744

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A nickel-catalyzed protocol for the conversion of aryl and heteroaryl alcohol derivatives to primary and secondary aromatic amines via C(sp(2))-O bond cleavage is described. The new amination protocol can be applied to a range of substrates bearing diverse functional groups and uses readily available benzophenone imines as an effective nitrogen source.

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