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Nitriles in Heterocyclic Synthesis. Synthesis and Reactions of Pyrano[3,2-h]quinoline Derivatives
Journal article   Peer reviewed

Nitriles in Heterocyclic Synthesis. Synthesis and Reactions of Pyrano[3,2-h]quinoline Derivatives

Z. H Khalil, A. A Abdel-Hafez, A. A Geies and A. M Kamal El-Dean
Bulletin of the Chemical Society of Japan, Vol.64(2), pp.668-670
01/02/1991
DOI: https://doi.org/10.1246/bcsj.64.668

Abstract

8-Quinolinol reacts with cinnamonitrile derivatives in presence of a basic catalyst to afford pyrano[3,2-h]quinolines (3a–f). The reaction of 3a with reagents such as acetic anhydride/pyridine, formamide, formic acid/formamide, and carbon disulfide gave the fused heterotetracyclic systems pyrimido[4′,5′: 6,5]pyrano[3,2-h]quinolines.

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