Non-carboxylic analogues of arylpropionic acids: Synthesis, anti-inflammatory activity and ulcerogenic potential

Kamel A. Metwally; Shada H. Yaseen; El-Sayed M. Lashine; Hassan M. El-Fayomi; Mohamed E. El-Sadek

doi:10.1016/j.ejmech.2006.09.001

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Non-carboxylic analogues of arylpropionic acids: Synthesis, anti-inflammatory activity and ulcerogenic potential

Journal article

Peer reviewed

Non-carboxylic analogues of arylpropionic acids: Synthesis, anti-inflammatory activity and ulcerogenic potential

Kamel A. Metwally, Shada H. Yaseen, El-Sayed M. Lashine, Hassan M. El-Fayomi and Mohamed E. El-Sadek

European journal of medicinal chemistry, Vol.42(2), pp.152-160

01/02/2007

DOI: https://doi.org/10.1016/j.ejmech.2006.09.001

PMID: 17052805

Abstract

Anti-inflammatory

Arylpropionic acids

Ulcerogenicity

Two series of 1,2,4-triazoles and 1,2,4-triazolo[3,4- b]-1,3,4-thiadiazoles derived from three selected arylpropionic acids namely, ibuprofen, flurbiprofen and naproxen, were synthesized and evaluated for anti-inflammatory activity and ulcerogenic potential. All the tested compounds exhibited anti-inflammatory activity comparable to that of hydrocortisone. Compared to ibuprofen, however, all the tested compounds displayed more potent anti-inflammatory activity. Compounds tested for ulcerogenicity showed no or minimal ulcerogenic effect compared to indomethacin. [Display omitted]

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Title: Non-carboxylic analogues of arylpropionic acids: Synthesis, anti-inflammatory activity and ulcerogenic potential
Creators - without role: Kamel A. Metwally - Zagazig University
Shada H. Yaseen - Zagazig University
El-Sayed M. Lashine - Zagazig University
Hassan M. El-Fayomi - Zagazig University
Mohamed E. El-Sadek - Zagazig University
Publication Details: European journal of medicinal chemistry, Vol.42(2), pp.152-160
Publisher: Elsevier Masson SAS
Identifiers: 9934081708331
Academic Unit: University of Tabuk
Language: English
Resource Type: Journal article