Sign in
Back
Nonpolar Solvent a Key for Highly Regioselective SNAr Reaction in the Case of 2,4-Difluoronitrobenzene
Journal article   Peer reviewed

Nonpolar Solvent a Key for Highly Regioselective SNAr Reaction in the Case of 2,4-Difluoronitrobenzene

Suresh Kumar Sythana, Surendra R. Naramreddy, Santosh Kavitake, Vinod C. H. Kumar and Pundlik R. Bhagat
Organic process research & development, Vol.18(7), pp.912-918
18/07/2014
DOI: https://doi.org/10.1021/op500120z

Abstract

Chemistry Chemistry, Applied Chemistry, Organic Physical Sciences Science & Technology
A practical and highly regioselective aromatic nucleophilic substitution reaction for the substrate 2,4-difluoronitrobenzene is demonstrated with various O/S/N-nucleophiles. Solvent screens substantiate the role of a nonpolar solvent in ortho-selective nucleophilic substitution through a six-membered polar transition state.

Metrics

1 Record Views

Details