Abstract
A series of new 2-phenyl-7-methyl-1,8-naphthyridine derivatives with variable substituents at C3 were synthesized for an
evaluation of their anticancer activity against human breast cancer cell line (MCF7). On one hand, compounds
,
,
, and
showed IC
values (6.53, 7.88, 7.89, 7.79 μM, respectively) compared to that of the mentioned drug staurosparine (IC
= 4.51 μM). On the other hand, derivatives
,
,
,
and
displayed better activity than staurosporin with IC
values (1.47, 1.62, 1.68, 2.30, 3.19 μM, respectively).