Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System

Hans Zimmer; Christian P. Librera; Sven Hausner; Jeanette Bauer; Adel Amer

doi:10.3390/81000735

Back

Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System

Journal article

Open access

Peer reviewed

Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System

Hans Zimmer, Christian P. Librera, Sven Hausner, Jeanette Bauer and Adel Amer

Molecules (Basel, Switzerland), Vol.8(10), pp.735-743

01/10/2003

DOI: https://doi.org/10.3390/81000735

PMCID: PMC6147071

Abstract

4-Aroyl-3-alkoxy-2(5H)-furanones

7-aryl-4,5-dihydro-2-oxo-3H

8H-furo-[3,4-b][1,4]diazepines

X-ray structures

A general synthesis of tetronic acid derivatives, namely 4-aroyl-3-alkoxy-2(5H)-furanones, is achieved via the treatment of an anhydrous dimethylformamide (DMF) solution of 4-aroyl-3-hydroxy-2(5H)-furanones with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base at -10-0°C, followed by the addition of alkyl iodide. Their structural assignments are based on spectroscopic data and confirmed by X-ray crystallography. These furanones were used as starting materials for the preparation of furodiazepines.

Files and links (1)

url

https://doi.org/10.3390/81000735View

Published (Version of record) Open

Metrics

1 Record Views

Details

Title: Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System
Creators - without role: Hans Zimmer - University of Cincinnati
Christian P. Librera - University of Cincinnati
Sven Hausner - University of Cincinnati
Jeanette Bauer
Adel Amer - Alexandria University
Publication Details: Molecules (Basel, Switzerland), Vol.8(10), pp.735-743
Publisher: MDPI
Identifiers: 9929449508331
Academic Unit: Taibah University
Language: English
Resource Type: Journal article