Abstract
A novel series of quinazoline derivatives
,
were designed and synthesized. Structures of the newly synthesized compounds were confirmed by elemental analyses, IR,
H and
C NMR spectral data. All the newly synthesized compounds were evaluated for
cytotoxic activity against the breast cancer cell line MCF-7. Seven of the novel compounds exhibited higher activity than the reference drug doxorubicin. The corresponding compounds
,
,
,
,
,
and
exhibited higher activity with
values from 22.75 to 43.44 μmol L
, compared to the reference drug doxorubicin with
value of 47.90 μmol L
. Also, compounds
,
, and
are nearly as active as doxorubicin with
values of 48.31, 48.90, and 48.91 μmol L
, respectively, while compounds
and
exhibited a moderate activity with
values of 50.44 and 52.37 μmol L
. In addition, compound
showed no activity. Cytotoxic screening of the tested copmpounds offered an encouraging framework that may lead to the discovery of potent anti-breast cancer activity.