Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Louise V. Wain; Ahmad Vaez; Rick Jansen; Roby Joehanes; Peter J. van der Most; A. Mesut Erzurumluoglu; Paul F. O'Reilly; Claudia P. Cabrera; Helen R. Warren; Lynda M. Rose; Germaine C. Verwoert; Jouke-Jan Hottenga; Rona J. Strawbridge; Tonu Esko; Dan E. Arking; Shih-Jen Hwang; Xiuqing Guo; Zoltan Kutalik; Stella Trompet; Nick Shrine; Alexander Teumer; Janina S. Ried; Joshua C. Bis; Albert V. Smith; Najaf Amin; Ilja M. Nolte; Leo-Pekka Lyytikainen; Anubha Mahajan; Nicholas J. Wareham; Edith Hofer; Peter K. Joshi; Kati Kristiansson; Michela Traglia; Aki S. Havulinna; Anuj Goel; Mike A. Nalls; Siim Sober; Dragana Vuckovic; Jian'an Luan; Fabiola Del Greco M; Kristin L. Ayers; Jaume Marrugat; Daniela Ruggiero; Lorna M. Lopez; Teemu Niiranen; Stefan Enroth; Anne U. Jackson; Christopher P. Nelson; Jennifer E. Huffman; Weihua Zhang; Jonathan Marten; Ilaria Gandin; Sarah E. Harris; Tatijana Zemunik; Yingchang Lu; Evangelos Evangelou; Nabi Shah; Martin H. de Borst; Massimo Mangino; Bram P. Prins; Archie Campbell; Ruifang Li-Gao; Ganesh Chauhan; Christopher Oldmeadow; Goncalo Abecasis; Maryam Abedi; Caterina M. Barbieri; Michael R. Barnes; Chiara Batini; John Beilby; Tineka Blake; Michael Boehnke; Erwin P. Bottinger; Peter S. Braund; Morris Brown; Marco Brumat; Harry Campbell; John C. Chambers; Massimiliano Cocca; Francis Collins; John Connell; Heather J. Cordell; Jeffrey J. Damman; Gail Davies; Eco J. de Geus; Renee de Mutsert; Joris Deelen; Yusuf Demirkale; Alex S. F. Doney; Marcus Dorr; Martin Farrall; Teresa Ferreira; Mattias Franberg; He Gao; Vilmantas Giedraitis; Christian Gieger; Franco Giulianini; Alan J. Gow; Anders Hamsten; Tamara B. Harris; Albert Hofman; Elizabeth G. Holliday; Jennie Hui; Marjo-Riitta Jarvelin; Åsa Johansson; Andrew D. Johnson; Pekka Jousilahti; Antti Jula; Mika Kahonen; Sekar Kathiresan; Kay-Tee Khaw; Ivana Kolcic; Seppo Koskinen; Claudia Langenberg; Marty Larson; Lenore J. Launer; Benjamin Lehne; David C. M. Liewald; Li Lin; Lars Lind; Francois Mach; Chrysovalanto Mamasoula; Cristina Menni; Borbala Mifsud; Yuri Milaneschi; Anna Morgan; Andrew D. Morris; Alanna C. Morrison; Peter J. Munson; Priyanka Nandakumar; Quang Tri Nguyen; Teresa Nutile; Albertine J. Oldehinkel; Ben A. Oostra; Elin Org; Sandosh Padmanabhan; Aarno Palotie; Guillaume Pare; Alison Pattie; Brenda W. J. H. Penninx; Neil Poulter; Peter P. Pramstaller; Olli T. Raitakari; Meixia Ren; Kenneth Rice; Paul M. Ridker; Harriette Riese; Samuli Ripatti; Antonietta Robino; Jerome I. Rotter; Igor Rudan; Yasaman Saba; Aude Saint Pierre; Cinzia F. Sala; Antti-Pekka Sarin; Reinhold Schmidt; Rodney Scott; Marc A. Seelen; Denis C. Shields; David Siscovick; Rossella Sorice; Alice Stanton; David J. Stott; Johan Sundström; Morris Swertz; Kent D. Taylor; Simon Thom; Ioanna Tzoulaki; Christophe Tzourio; Andre G. Uitterlinden; Uwe Volker; Peter Vollenweider; Sarah Wild; Gonneke Willemsen; Alan F. Wright; Jie Yao; Sebastien Theriault; David Conen; John Attia; Peter Sever; Stephanie Debette; Dennis O. Mook-Kanamori; Eleftheria Zeggini; Tim D. Spector; Pim van der Harst; Colin N. A. Palmer; Anne-Claire Vergnaud; Ruth J. F. Loos; Ozren Polasek; John M. Starr; Giorgia Girotto; Caroline Hayward; Jaspal S. Kooner; Cecila M. Lindgren; Veronique Vitart; Nilesh J. Samani; Jaakko Tuomilehto; Ulf Gyllensten; Paul Knekt; Ian J. Deary; Marina Ciullo; Roberto Elosua; Bernard D. Keavney; Andrew A. Hicks; Robert A. Scott; Paolo Gasparini; Maris Laan; YongMei Liu; Hugh Watkins; Catharina A. Hartman; Veikko Salomaa; Daniela Toniolo; Markus Perola; James F. Wilson; Helena Schmidt; Jing Hua Zhao; Terho Lehtimaki; Cornelia M. van Duijn; Vilmundur Gudnason; Bruce M. Psaty; Annette Peters; Rainer Rettig; Alan James; J. Wouter Jukema; David P. Strachan; Walter Palmas; Andres Metspalu; Erik Ingelsson; Dorret I. Boomsma; Oscar H. Franco; Murielle Bochud; Christopher Newton-Cheh; Patricia B. Munroe; Paul Elliott; Daniel I. Chasman; Aravinda Chakravarti; Joanne Knight; Andrew P. Morris; Daniel Levy; Martin D. Tobin; Harold Snieder; Mark J. Caulfield; Georg B. Ehret; T. Y. Alistair; J. -P Betholdson; Limin Xiao; Lifelines Cohort Study

doi:10.1161/HYPERTENSIONAHA.117.09438

Back

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Journal article

Open access

Peer reviewed

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Louise V. Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, A. Mesut Erzurumluoglu, Paul F. O'Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose, …

Hypertension (Dallas, Tex. 1979), Vol.70(3), pp.E4-+

01/09/2017

DOI: https://doi.org/10.1161/HYPERTENSIONAHA.117.09438

PMID: 28739976

Abstract

blood pressure

Cardiac and Cardiovascular Systems

cardiovascular risk

Clinical Medicine

complex traits

eSNP

GWAS

hypertension

Kardiologi

Klinisk medicin

Medical and Health Sciences

Medicin och hälsovetenskap

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.

Files and links (1)

url

https://doi.org/10.1161/HYPERTENSIONAHA.117.09438View

Published (Version of record) Open

Metrics

1 Record Views

See more details

Details

Title: Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
Creators - without role: Louise V. Wain - University of Leicester
Ahmad Vaez
Rick Jansen - University of Amsterdam
Roby Joehanes
Peter J. van der Most - University of Groningen
A. Mesut Erzurumluoglu - University of Leicester
Paul F. O'Reilly - Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England. Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Claudia P. Cabrera
Helen R. Warren
Lynda M. Rose - Brigham and Women's Hospital
Germaine C. Verwoert - Erasmus MC
Jouke-Jan Hottenga - College Station Medical Center
Rona J. Strawbridge
Tonu Esko
Dan E. Arking - Johns Hopkins University
Shih-Jen Hwang
Xiuqing Guo - College Station Medical Center
Zoltan Kutalik
Stella Trompet
Nick Shrine - University of Leicester
Alexander Teumer
Janina S. Ried - Helmholtz Zentrum München
Joshua C. Bis - University of Washington
Albert V. Smith
Najaf Amin - Erasmus MC
Ilja M. Nolte - University of Groningen
Leo-Pekka Lyytikainen
Anubha Mahajan - University of Oxford
Nicholas J. Wareham - University of Cambridge
Edith Hofer
Peter K. Joshi - University of Edinburgh
Kati Kristiansson - Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland
Michela Traglia - Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy
Aki S. Havulinna - Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland
Anuj Goel
Mike A. Nalls
Siim Sober - University of Tartu
Dragana Vuckovic
Jian'an Luan - University of Cambridge
Fabiola Del Greco M - University of Lübeck
Kristin L. Ayers
Jaume Marrugat
Daniela Ruggiero - CNR, Inst Genet & Biophys A Buzzati Traverso, Naples, Italy
Lorna M. Lopez
Teemu Niiranen - Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland
Stefan Enroth - Science for Life Laboratory
Anne U. Jackson
Christopher P. Nelson
Jennifer E. Huffman
Weihua Zhang
Jonathan Marten
Ilaria Gandin - University of Trieste
Sarah E. Harris
Tatijana Zemunik - London North West Healthcare NHS Trust
Yingchang Lu - Supreme Council Of Health
Evangelos Evangelou
Nabi Shah
Martin H. de Borst - University of Groningen
Massimo Mangino - Natl Inst Hlth Res, Biomed Res Ctr, London, England
Bram P. Prins - Wellcome Sanger Institute
Archie Campbell
Ruifang Li-Gao - Leiden University
Ganesh Chauhan
Christopher Oldmeadow - College Station Medical Center
Goncalo Abecasis - Biostat
Maryam Abedi - College Station Medical Center
Caterina M. Barbieri - Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy
Michael R. Barnes
Chiara Batini - University of Leicester
John Beilby
Tineka Blake - University of Leicester
Michael Boehnke
Erwin P. Bottinger - Supreme Council Of Health
Peter S. Braund
Morris Brown
Marco Brumat - University of Trieste
Harry Campbell - University of Edinburgh
John C. Chambers
Massimiliano Cocca - University of Trieste
Francis Collins - College Station Medical Center
John Connell - University of Dundee
Heather J. Cordell - Newcastle University
Jeffrey J. Damman - College Station Medical Center
Gail Davies
Eco J. de Geus - College Station Medical Center
Renee de Mutsert - Leiden University
Joris Deelen - Leiden University
Yusuf Demirkale - NIH, Ctr Informat Technol, Bldg 10, Bethesda, MD 20892 USA
Alex S. F. Doney
Marcus Dorr
Martin Farrall
Teresa Ferreira
Mattias Franberg
He Gao - Supreme Council Of Health
Vilmantas Giedraitis - Geriatrik
Christian Gieger - Forschungszentrum Gesundheit & Umwelt GmbH, Neuherberg, Germany
Franco Giulianini - Brigham and Women's Hospital
Alan J. Gow
Anders Hamsten
Tamara B. Harris - NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
Albert Hofman
Elizabeth G. Holliday - College Station Medical Center
Jennie Hui
Marjo-Riitta Jarvelin
Åsa Johansson - Medicinsk genetik och genomik
Andrew D. Johnson
Pekka Jousilahti - Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland
Antti Jula - Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland
Mika Kahonen
Sekar Kathiresan
Kay-Tee Khaw - University of Cambridge
Ivana Kolcic - University of Split
Seppo Koskinen - Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland
Claudia Langenberg - University of Cambridge
Marty Larson - Framingham Heart Dis Epidemiol Study, Natl Heart Lung & Blood Inst, Framingham, MA USA
Lenore J. Launer - NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
Benjamin Lehne - Supreme Council Of Health
David C. M. Liewald
Li Lin - College Station Medical Center
Lars Lind - Kardiovaskulär epidemiologi
Francois Mach - College Station Medical Center
Chrysovalanto Mamasoula - Newcastle University
Cristina Menni
Borbala Mifsud - William Harvey Research Institute
Yuri Milaneschi - University of Amsterdam
Anna Morgan - University of Trieste
Andrew D. Morris - University of Edinburgh
Alanna C. Morrison - Supreme Council Of Health
Peter J. Munson - NIH, Ctr Informat Technol, Bldg 10, Bethesda, MD 20892 USA
Priyanka Nandakumar - Johns Hopkins University
Quang Tri Nguyen
Teresa Nutile - CNR, Inst Genet & Biophys A Buzzati Traverso, Naples, Italy
Albertine J. Oldehinkel - University of Groningen
Ben A. Oostra - Erasmus MC
Elin Org - University of Tartu
Sandosh Padmanabhan
Aarno Palotie - University of Helsinki
Guillaume Pare - McMaster University
Alison Pattie - University of Edinburgh
Brenda W. J. H. Penninx - University of Amsterdam
Neil Poulter - Supreme Council Of Health
Peter P. Pramstaller
Olli T. Raitakari
Meixia Ren
Kenneth Rice - University of Washington
Paul M. Ridker
Harriette Riese - University of Groningen
Samuli Ripatti - University of Helsinki
Antonietta Robino - Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Trieste, Italy
Jerome I. Rotter - College Station Medical Center
Igor Rudan - University of Edinburgh
Yasaman Saba - University of Graz
Aude Saint Pierre
Cinzia F. Sala - Mylan
Antti-Pekka Sarin - University of Helsinki
Reinhold Schmidt - University of Graz
Rodney Scott
Marc A. Seelen - University of Groningen
Denis C. Shields - Supreme Council Of Health
David Siscovick - College Station Medical Center
Rossella Sorice
Alice Stanton - Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin 2, Ireland
David J. Stott - University of Glasgow
Johan Sundström - Kardiovaskulär epidemiologi
Morris Swertz - University of Groningen
Kent D. Taylor
Simon Thom - Imperial Coll London, Int Ctr Circulatory Hlth, London, England
Ioanna Tzoulaki - Supreme Council Of Health
Christophe Tzourio
Andre G. Uitterlinden
Uwe Volker
Peter Vollenweider - University of Lausanne
Sarah Wild - University of Edinburgh
Gonneke Willemsen - College Station Medical Center
Alan F. Wright
Jie Yao - College Station Medical Center
Sebastien Theriault - McMaster University
David Conen - McMaster University
John Attia
Peter Sever - Lung Institute
Stephanie Debette
Dennis O. Mook-Kanamori
Eleftheria Zeggini - Wellcome Sanger Institute
Tim D. Spector
Pim van der Harst - University of Groningen
Colin N. A. Palmer
Anne-Claire Vergnaud - Supreme Council Of Health
Ruth J. F. Loos
Ozren Polasek - University of Split
John M. Starr
Giorgia Girotto
Caroline Hayward
Jaspal S. Kooner
Cecila M. Lindgren
Veronique Vitart
Nilesh J. Samani
Jaakko Tuomilehto
Ulf Gyllensten - Medicinsk genetik och genomik
Paul Knekt - Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland
Ian J. Deary
Marina Ciullo
Roberto Elosua
Bernard D. Keavney - University of Manchester
Andrew A. Hicks - University of Lübeck
Robert A. Scott - University of Cambridge
Paolo Gasparini
Maris Laan - University of Tartu
YongMei Liu - Supreme Council Of Health
Hugh Watkins
Catharina A. Hartman - University of Groningen
Veikko Salomaa - Dept Hlth, Helsinki, Finland. Chron Dis Prevent Unit, Helsinki, Finland. Natl Inst Hlth & Welf, Helsinki, Finland
Daniela Toniolo - Ist Sci San Raffaele, Div Genet & Cell Biol, Milan, Italy
Markus Perola
James F. Wilson - University of Edinburgh
Helena Schmidt
Jing Hua Zhao - University of Cambridge
Terho Lehtimaki
Cornelia M. van Duijn - Erasmus MC
Vilmundur Gudnason
Bruce M. Psaty
Annette Peters - Helmholtz Zentrum München
Rainer Rettig - College Station Medical Center
Alan James
J. Wouter Jukema - Leiden University
David P. Strachan - University of London
Walter Palmas - Columbia University
Andres Metspalu - University of Tartu
Erik Ingelsson - Science for Life Laboratory
Dorret I. Boomsma - College Station Medical Center
Oscar H. Franco - Erasmus MC
Murielle Bochud - University of Lausanne
Christopher Newton-Cheh
Patricia B. Munroe
Paul Elliott - Supreme Council Of Health
Daniel I. Chasman
Aravinda Chakravarti - Johns Hopkins University
Joanne Knight
Andrew P. Morris
Daniel Levy
Martin D. Tobin
Harold Snieder - University of Groningen
Mark J. Caulfield
Georg B. Ehret
T. Y. Alistair
J. -P Betholdson
Limin Xiao
Lifelines Cohort Study
Publication Details: Hypertension (Dallas, Tex. 1979), Vol.70(3), pp.E4-+
Identifiers: 9938562208331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article