Abstract
Condensation of the reaction between enrofloxacin and ethylenediamine in the existence of glacial acetic acid produced a new N,N-ethylene (bis 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-1,4-dihydroquinoline-3-carboxylic acid Schiff base (H(2)Erx-en). H(2)Erx-en was used as a tetra-dentate ligand to produce novel complexes by interacting with metal ions iron(III), yttrium(III), zirconium(IV), and lanthanum(III). The synthetic H(2)Erx-en and its chelates had been detected with elemental analysis, spectroscopic methods, mass spectrometry, thermal studies, conductometric and magnetic measurements experiments. The calculated molar conductance of the complexes in 1 x 10(-3) M DMF solution shows that iron(III), yttrium(III) and lanthanum(III) are 1:1 electrolytes, however the zirconium(IV) complex is non-electrolyte. The infrared spectra of H(2)Erx-en chelates indicated that the carboxylic group is deprotonated and H(2)Erx-en is associated with metals as a tetra-dentate through nitrogen and oxygen atoms. The disappearance of the carboxylic proton in all complexes corroborated information concerning H(2)Erx-en deprotonation and complexation with metal ions, according to H-1 NMR data. Thermal analysis revealed the abundance of H2O particles in the chelates' entrance and outlet spheres, indicating the disintegration pattern of H(2)Erx-en and their chelates. The Coats-Redfern and Horowitz-Metzeger approaches were utilized to calculate the thermodynamic items (E-a, Delta S *, Delta H *, and Delta G *) at n = 1 and n not equal 1. The resulting data reveal better organized chelate building activation. Density functional theory (DFT) was created to properly grasp the optimal architecture of the molecules. The chelates are softer than H(2)Erx-en, with estimates varying between 95.23 eV to 400.00 eV, compared to 31.47 eV for H(2)Erx-en. The disc diffusion technique was utilized to assess H(2)Erx-en and their chelates in an antimicrobial assay against various food and phytopathogens. The zirconium(IV) chelate has the most potent antibacterial action and is particularly efficient against Salmonella typhi.