Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives

A. Chris Krueger; Darold L. Madigan; David W. Beno; David A. Betebenner; Robert Carrick; Brian E. Green; Wenping He; Dachun Liu; Clarence J. Maring; Keith F. McDaniel; Hongmei Mo; Akhteruzzaman Molla; Christopher E. Motter; Tami J. Pilot-Matias; Michael D. Tufano; Dale J. Kempf

doi:10.1016/j.bmcl.2012.01.096

Back

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives

Journal article

Peer reviewed

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives

A. Chris Krueger, Darold L. Madigan, David W. Beno, David A. Betebenner, Robert Carrick, Brian E. Green, Wenping He, Dachun Liu, Clarence J. Maring, Keith F. McDaniel, …

Bioorganic & medicinal chemistry letters, Vol.22(6), pp.2212-2215

15/03/2012

DOI: https://doi.org/10.1016/j.bmcl.2012.01.096

PMID: 22342631

Abstract

Chemistry

Chemistry, Medicinal

Chemistry, Organic

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Physical Sciences

Science & Technology

The synthesis of several pyrido[2,3-d] pyrimidine and pyrimido[4,5-d] pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays. (C) 2012 Elsevier Ltd. All rights reserved.

Metrics

1 Record Views

Details

Title: Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives
Creators - without role: A. Chris Krueger - Abbott
Darold L. Madigan - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
David W. Beno - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
David A. Betebenner - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
Robert Carrick - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
Brian E. Green - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
Wenping He - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
Dachun Liu - Abbott
Clarence J. Maring - Abbott
Keith F. McDaniel - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
Hongmei Mo - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
Akhteruzzaman Molla - Abbott
Christopher E. Motter - Abbott
Tami J. Pilot-Matias - Abbott
Michael D. Tufano - Abbott
Dale J. Kempf - Abbott Labs, Global Pharmaceut Res & Dev, Dept R4DH, Abbott Pk, IL 60064 USA
Publication Details: Bioorganic & medicinal chemistry letters, Vol.22(6), pp.2212-2215
Publisher: Elsevier
Number of pages: 4
Identifiers: 9944385808331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article