Abstract
Novel clozapine ion selective electrode was fabricated, characterized and used for determination of clozapine in its pharmaceutical formulations. The proposed sensor incorporated clozapine phosphotungstate ion pair complex as electroactive material in PVC matrix membrane and dioctylsebacate as solvent mediator. The resulting electrode demonstrates near –Nernstain response over wide linear range (10-5–10-2 M) clozapine with lower limit of detection of 3.7 x 10-6 M and slope of 57.46 ±0.1 mV/ decade. Fast and stable response, good reproducibility, long term stability (4 months) and applicability over a wide pH range (4.5-8). The sensor displayed a good selectivity for clozapine with respect to number of common foreign inorganic, organic species, excepients and the fillers added to the pharmaceutical preparation fortunately, such materials mostly do not interfere. The sensors were successfully applied for the determination of clozapine in its tablets.