Abstract
Hyperlipidemia is nowadays one of the main risk factors for cardiovascular diseases. Therefore, synthesis of new compounds with potential lowering effect on blood lipid profiles became a major concern for many researchers. In this study, we were able to synthesize, characterize and validate new series of novel pyrrole derivatives and evaluate their potency as lipid-lowering agents on animal model. Hyperlipidemia was induced in rats using Triton WR-1339 (Tyloxapol). After 18 h and at a dose of 15 mg/kg body weight, C5, C7 and bezafibrate (100 mg/kg) significantly (p < 0.0001) reduced the elevated plasma TG as well as that of plasma total cholesterol and LDL levels compared to the hyperlipidemic control group. Promisingly, C5 and C7 were also able to increase HDL level compared to the hyperlipidemic control group. These results insights potential hypolipidemic effects which consequently may contribute as protective agents against atherosclerosis and cardiovascular diseases.