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Novel Uncatalyzed Hydrocyanation of Ketones utlizing Tetrachlorosilane-Potassium Cyanide Reagent
Journal article   Peer reviewed

Novel Uncatalyzed Hydrocyanation of Ketones utlizing Tetrachlorosilane-Potassium Cyanide Reagent

Tarek A. Salama, Saad S. Elmorsy, Abdel-Galel M. Khalil, Margret M. Girges and Abdel-Aziz S. El-Ahl
Synthetic communications, Vol.37(8), pp.1313-1319
01/04/2007

Abstract

A combination of tetrachlorosilane and potassium cyanide (in situ trichlorosilyl cyanide) was found to work efficiently for hydrocyanation of ketones to afford the corresponding cyanohydrins in high yield under mild conditions.

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