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Novel antibacterial active quinolone–fluoroquinolone conjugates and 2D-QSAR studies
Journal article   Peer reviewed

Novel antibacterial active quinolone–fluoroquinolone conjugates and 2D-QSAR studies

Siva S. Panda, Sumaira Liaqat, Adel S. Girgis, Ahmed Samir, C. Dennis Hall and Alan R. Katritzky
Bioorganic & medicinal chemistry letters, Vol.25(18), pp.3816-3821
15/09/2015
DOI: https://doi.org/10.1016/j.bmcl.2015.07.077
PMID: 26253630

Abstract

Amino acids Anti-bacterial Conjugates Fluoroquinolone QSAR Quinolone
[Display omitted] Novel, quinolone–fluoroquinolone conjugates 10a–f, 11a–f, 13a–f and 14a–f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.

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