Abstract
A new optical chemical sensor based on medicinal compound, jaeschkeanadiol p-hydroxyben-zoate (Ferutinin), has been designed and utilized for Ca(II) ions detections. This natural optical sensor exhibits immense selectivity including fluorescence and absorption ratiometric for Ca(II) ions within precious physiological pH range. Further, the chelation process of the Ca(II) ions with the medicinal optical sensor ferutinin yields a 1:1 (metal: ligand) complex which is accompanied by fluorescence enhancement of the main emission band centered at 355 nm of the medicinal probe. The fluorescence “turn-on” effect is a clear evidence for the chelation process between ferutinin medicinal probe and Ca(II) ions and this could be simply detected. The new sensor was proposed depending on significant fluorescence mechanism, (MLCT, metal-ligand charge transfer). However, the interaction of the medicinal optical sensor with Ca(II) in presence of other cations was examined without any significant interference. Also, the new developed optical sensor consecutively exhibits low limit of detection (LOD) 1.5 nM for Ca(II) which is detected in very significant physiological pH range (pH = 7.4). Also, the probe provides high binding affinity towards Ca(II) with large binding constant Kb 5.97 × 104 M−1. As a result, this optical sensor may apply for detection Ca(II) in cell or biological samples.
A novel optical chemical sensor was developed for Ca(II) ions detection. The chemosensor is designed based on jaeschkeanadiol p-hydroxyben-zoate, Ferutinin (Fh-25). The chemosensor probe shows high selectivity, sensitivity and reversibility depending on their fluorescence properties and recognition abilities within very low detection (LOD 1.5 nM) in physiological pH = 7.4. [Display omitted]
•A novel optical chemical sensor based ferutinin medical probe for Ca(II) detection was developed.•The sensor provides fast response, high sensitivity and selectivity.•LOD was detected in nanomolar range (1.5 nM for Ca(II)).•The sensing mechanism of the Medical probe for Ca(II) is MLCT as suggested.