Abstract
In the current work, the synthesis, characterization, and biological activities of a novel series of isoxazoles connected to benzodiazepines are described. These compounds structures were identified using 1H NMR, C-13 NMR, X-Ray, and HRMS. All the new synthesized compounds were screened for their antimicrobial activities against three types of pathogenic bacteria and three fungal strains, by application of the DiscDiffusion and MIC assays, using Ampicillin and Griseofulvin as standard. Biological results revealed that some of these compounds exhibited excellent to moderate antimicrobial activities. The interactions of these compounds with the Gram-positive bacteria Bacillus subtilus (ATCC 6633) and the Gram-negative bacteria Pseudomonas aeruginosa (ATCC 27,853) were performed by molecular docking studies. Published by Elsevier B.V.