Abstract
In pharmaceutical industry, finding promising ways to enhance the solubility of disparate types of drugs is an important challenge for the orally administered drug delivery system. Disparate techniques based on drug characteristics, nature of dosage form and properties of excipients have recently been under extensive evaluation all over the world to improve the solubility of poorly water-soluble drugs. Among them, supercritical fluid carbon dioxide (SC-CO2) has received para-mount attentions due to having considerable advantages like cost-effectiveness and low flammability. Lenalidomide belongs is an orally administered anti-cancer agent, which has recently received indication for the treatment of adult patients with different bone marrow-related malignancies such as multiple myeloma, mantle cell lymphoma and follicular lymphoma. Predicting the optimized value of Lenalidomide inside the SC-CO2 in a wide range of pressure and temperature via developing mathematical models based on artificial intelligence (AI) is the main objective of this paper. In this study, three different machine learning based models are selected to predict and optimized the drug solubility. The available data includes 28 rows of data with two inputs including temperature and pressure and two outputs including density and solubility. Selected models are Kernel Ridge Regression (KRR), least angle regression (LAR), and Multilayer Perceptron (MLP). After optimizing models and comparing the results, the MLP was selected as the primary model of this research. The models illustrated R-squared scores of 0.999 and 0.994 for density and solubility. The maxi-mum errors are also 2.92 and 6.44 x 10(-2) for these outputs, which shows the accuracy and significant generality of the model. (C) 2022 The Authors. Published by Elsevier B.V. on behalf of King Saud University.