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Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents
Journal article   Peer reviewed

Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents

Saleh I. Alqasoumi, Areej M. Al-Taweel, Ahmed M. Alafeefy, Eman Noaman and Mostafa M. Ghorab
European journal of medicinal chemistry, Vol.45(2), pp.738-744
01/02/2010
DOI: https://doi.org/10.1016/j.ejmech.2009.11.021
PMID: 19944497

Abstract

Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds 24,19 and 12 showed higher activity with IC50 values (5.5, 6.9, 7 mu g/ml) when compared with Doxorubicin as a reference drug (IC50 value 38 mu g/ml). (C) 2009 Elsevier Masson SAS. All rights reserved.

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