Abstract
The high toxicity and side effects of the most widely used cancer chemotherapeutic drug (Cisplatin, CDDP) induced always an urgent need for exploring new safe chemotherapeutic agents (CTAs). To that end, a novel series of physiologically stable and water-soluble thiazolium ionic liquids (ILs)-tagged Schiff bases ( 3a-c ) and their bicyclo-palladium(II) complexes ( 4a-c ) were synthesized with high yields and their physicochemical characteristics were determined using diverse analytical techniques. New thiazolium ILsbased congeners were in vitro assessed as CTAs for ovarian carcinoma cell line (SKOV-3). For selectivity level checking, the effect of these compounds on normal human skin fibroblast cells (HSF) was also investigated. It can be highlighted that all thiazolium derivatives induced a dose-and time-dependent decline in SKOV-3 cell viability with a preferable efficacy for Pd(II) complexes over their corresponding thiazolium Schiff bases. In addition, the new compounds showed excellent selectivity for cancer cells (SKOV-3) over the healthy cells (HSF). (c) 2021 Elsevier B.V. All rights reserved.