Abstract
With reporter cell lines developed in the lab and allowing the detection of specific activities, we characterized the endocrine disrupting profile of waters, particulate matter and sediments from tow Tunisian sewage treatment plants (STPs), which inputs were of domestic and touristic origins. We used bioluminescent chimeric cell lines to detect ligands of the estrogen and xenobiotic receptors. The STP waters exhibited a very high estrogenic activity whereas particulate matter and sediments showed a strong xenobiotic activity, mediated by pregnane X receptor. (C) 2010 Elsevier Masson SAS. All rights reserved.