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Old Dog, New Trick: Type I IFN-Based Treatment for Acute Myeloid Leukemia
Journal article   Open access  Peer reviewed

Old Dog, New Trick: Type I IFN-Based Treatment for Acute Myeloid Leukemia

Abdullah Alsufyani, Rehab Alanazi, John F Woolley and Lekh N Dahal
Molecular cancer research, Vol.19(5), pp.753-756
05/2021
DOI: https://doi.org/10.1158/1541-7786.MCR-20-0871
PMID: 33500358

Abstract

Animals Humans Interferon Type I - pharmacology Interferon Type I - therapeutic use Leukemia, Myeloid, Acute - drug therapy Mice
Despite strong biological rationale for the use of type-I IFNs for the treatment of acute myeloid leukemia (AML), their usage is limited to few hematologic malignancies. Here, we propose that innate immune sensing machinery, particularly the stimulator of IFN genes pathway, may be exploited to deliver antileukemic effects in AML.
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https://doi.org/10.1158/1541-7786.MCR-20-0871View
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