Abstract
Proton pump inhibitors are one of the most widely used antisecretory agents used in the treatment of hyperacidity. These proton inhibitors have direct propulsive effect on gastrointestinal bacteria towards liver in absence of gastric acid. The report is about a patient suffering from Gastro-oesophageal Reflux Disease (GERD) receiving ranitidine and omeprazole. On measuring the biomarkers of liver function, the serum levels of Alanine Aminotransferase (ALT), Aspartate Aminotransf erase (AST), Gamma Glutamyl Transferase (GGT), Albumin to Globulin Ratio (A/G ratio), cholesterol and creatinine were found to be increased. After cessation of the treatment with PPIs, diet regulation and usage of herbal products, the biomarker levels decreased and after another one month ALT and AST returned to normal.