Abstract
Owing to their wide range of biological properties, γ‐aminobutyric acid derivatives (GABA) have been extensively studied and found noteworthy industrial applications. However, atom‐economical and efficient processes for their production are scarce and would greatly benefit from further investigations. Herein, we demonstrate that an iridium‐based photocatalyst promotes the direct reductive cross‐coupling of imines with olefins upon irradiation with visible light to give GABA derivatives in good yields and selectivities. We also stress the enabling triple role of tributylamine additive in this process, discuss the advantages of strategies based on proton‐coupled electron transfer (PCET) and demonstrate the scale‐up of this reaction in continuous flow.
One amine–3 tasks: Gamma‐aminobutyric acid derivatives could easily be synthesized by the visible‐light photoredox‐catalyzed coupling of imines with olefins. The reaction works well for a range of substrates and tolerates many functional groups. A continuous‐flow strategy considerably improved the efficiency of this methodology.