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One-Pot Combination of the Wittig Olefination with Bromination and Oxidation Reactions
Journal article   Peer reviewed

One-Pot Combination of the Wittig Olefination with Bromination and Oxidation Reactions

Usama Karama, Refat Mahfouz, Zeid Al-Othman, Ismail Warad and Abdulrahman Almansour
Synthetic communications, Vol.43(6), pp.893-898
01/02/2013
DOI: https://doi.org/10.1080/00397911.2011.614712

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A simple one-pot process for in situ bromination of (ethoxycarbonylmethylene)-triphenylphosphorane 1 was carried out. This was followed by oxidation of alcohol using SO3. Pyridine complex as a mild oxidant and in situ trapping of the aldehyde. This process constitutes a stereoselective one-pot procedure for the preparation of Z-configured a-bromo-a, beta-unsaturated esters in good yield.

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