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One-Pot Decarboxylative Acylation of N-, O-, S-Nucleophiles and Peptides with 2,2-Disubstituted Malonic Acids
Journal article   Peer reviewed

One-Pot Decarboxylative Acylation of N-, O-, S-Nucleophiles and Peptides with 2,2-Disubstituted Malonic Acids

Iryna O. Lebedyeva, Suvendu Biswas, Kevin Goncalves, Sean M. Sileno, Ashton R. Jackson, Kunal Patel, Peter J. Steel and Alan R. Katritzky
Chemistry : a European journal, Vol.20(37), pp.11695-11698
08/09/2014
DOI: https://doi.org/10.1002/chem.201403529
PMID: 25065781

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
Monocarbonyl activation of 2,2-disubstituted malonic acids with benzotriazole leads to decarboxylation of one of the carboxy groups and formation of a C-H bond. Intermediate carbonyl benzotriazoles then readily acylate nucleophilic reagents and peptides resulting in libraries of conjugates and peptidomimetics.

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