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One-Pot Reaction of Amidrazones, Phthaloyl Chloride, and Triethyl Amine: Synthesis of 1-(1,2,4-Triazole)-2-Benzoic Acid
Journal article   Peer reviewed

One-Pot Reaction of Amidrazones, Phthaloyl Chloride, and Triethyl Amine: Synthesis of 1-(1,2,4-Triazole)-2-Benzoic Acid

Ashraf A. Aly, Alan B. Brown and Ahmed M. Shawky
Journal of heterocyclic chemistry, Vol.54(4), pp.2375-2379
01/07/2017

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
One-pot reaction of equimolar amounts of phthaloyl chloride and N-aryl-benzamidrazones in the presence of two equivalents of triethylamine (Et3N), gave at r.t. 4-aryl-3-(o-carboxyphenyl)-5-phenyl-1,2,4-triazoles in good yields. The structure of the obtained products was proved by IR, mass, NMR spectra, and elemental analyses. The mechanism of product formation is discussed.

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