Abstract
A novel series of
(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between
-hydrazonoyl chloride
and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the
-thiadiazole derivatives
,
,
,
and
had higher antitumor activity than the standard drug Imatinib.