One-pot efficient synthesis of N (alpha)-urethane-protected beta- and gamma-amino acids

Marta Cal; Mariusz Jaremko; Lukasz Jaremko; Piotr Stefanowicz

doi:10.1007/s00726-012-1443-3

Back

One-pot efficient synthesis of N (alpha)-urethane-protected beta- and gamma-amino acids

Journal article

Open access

Peer reviewed

One-pot efficient synthesis of N (alpha)-urethane-protected beta- and gamma-amino acids

Marta Cal, Mariusz Jaremko, Lukasz Jaremko and Piotr Stefanowicz

Amino acids, Vol.44(3), pp.1085-1091

01/03/2013

DOI: https://doi.org/10.1007/s00726-012-1443-3

PMID: 23250684

Abstract

Biochemistry & Molecular Biology

Life Sciences & Biomedicine

Science & Technology

1-[(4-Methylphenyl)oxy]pyrrolidine-2,5-dione and 1-[(4-methylphenyl)oxy]piperidine-2,6-dione react in a Lossen-type reaction with primary alcohols in the presence of triethylamine to furnish corresponding N (alpha)-urethane-protected beta-alanine and gamma-aminopropionic acid (GABA), respectively, with excellent yields and purities, in an essentially "one-pot" procedure.

Files and links (1)

url

https://doi.org/10.1007/s00726-012-1443-3View

Published (Version of record) Open

Metrics

1 Record Views

Details

Title: One-pot efficient synthesis of N (alpha)-urethane-protected beta- and gamma-amino acids
Creators - without role: Marta Cal - University of Wrocław
Mariusz Jaremko - Polish Academy of Sciences
Lukasz Jaremko - Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland
Piotr Stefanowicz - University of Wrocław
Publication Details: Amino acids, Vol.44(3), pp.1085-1091
Publisher: Springer Nature
Number of pages: 7
Grant note: Faculty of Chemistry of Wroclaw University, Wroclaw, Poland
Identifiers: 9945532008331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article