One-pot, simple and efficient synthesis of novel bioactive 4-aryl-1,2-dihydro-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxopyridin-3-carbonitriles via multi-component approach

Ichraf Slimani; Salwa Hamzaoui; Lamjed Mansour; Abdel Halim Harrath; Naceur Hamdi

doi:10.1016/j.jksus.2019.11.023

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One-pot, simple and efficient synthesis of novel bioactive 4-aryl-1,2-dihydro-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxopyridin-3-carbonitriles via multi-component approach

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One-pot, simple and efficient synthesis of novel bioactive 4-aryl-1,2-dihydro-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxopyridin-3-carbonitriles via multi-component approach

Ichraf Slimani, Salwa Hamzaoui, Lamjed Mansour, Abdel Halim Harrath and Naceur Hamdi

Journal of King Saud University. Science, Vol.32(1), pp.1212-1217

01/2020

DOI: https://doi.org/10.1016/j.jksus.2019.11.023

Abstract

4-Hydroxycoumarin

Antibacterial and acetylcholinesterase inhibition activities

Ethyl cyanoacetate

Multicomponent reaction

Quantitative multicomponent cyclocondensation of 3-acetyl-4-hydroxycoumarine with ethyl cyanoacetate and aryldehydes has been carried out in ammonium acetate, at reflux. [Display omitted] Quantitative multicomponent cyclocondensation of 3-acetyl-4-hydroxycoumarine with ethyl cyanoacetate and aryldehydes has been carried out in ammonium acetate, at reflux. The optimization details of the developed novel protocol are recorded. The structure of newly synthesized compounds have been characterized by spectroscopic data (elemental analysis, IR and 1H NMR spectroscopic studied). Antimicrobial properties of the novel coumarins derivatives 3 are investigated. The acetylcholinesterase inhibition activity (AChEI) was tested for all compounds, and the 3b shows the highest AChEI activity with 48.25% of inhibition.

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Title: One-pot, simple and efficient synthesis of novel bioactive 4-aryl-1,2-dihydro-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxopyridin-3-carbonitriles via multi-component approach
Creators - without role: Ichraf Slimani - University of Carthage
Salwa Hamzaoui - University of Carthage
Lamjed Mansour - King Saud University
Abdel Halim Harrath - King Saud University
Naceur Hamdi - University of Carthage
Publication Details: Journal of King Saud University. Science, Vol.32(1), pp.1212-1217
Publisher: Elsevier B.V
Identifiers: 9928861408331
Academic Unit: Qassim University
Language: English
Resource Type: Journal article