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One-pot synthesis of 2,3,4,5,6-pentasubstituted tetrahydropyrans using lithiation-borylation, allylation and Prins cyclisation reactions
Journal article   Peer reviewed

One-pot synthesis of 2,3,4,5,6-pentasubstituted tetrahydropyrans using lithiation-borylation, allylation and Prins cyclisation reactions

Adeem Mahmood, Jose Ramon Suarez, Stephen P. Thomas and Varinder K. Aggarwal
Tetrahedron letters, Vol.54(1), pp.49-51
02/01/2013
DOI: https://doi.org/10.1016/j.tetlet.2012.10.091

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
2,3,4,5,6-Pentasubstituted tetrahydropyrans have been prepared in good yield (42-57%) with excellent dr (>95:5) and er (>95:5) using a one-pot lithiation-borylation, allylation and Prins cyclisation reaction. (C) 2012 Elsevier Ltd. All rights reserved.

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