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One-pot synthesis of beta-amido ketones using Bronsted acidic ionic liquid as an efficient and reusable catalyst
Journal article   Peer reviewed

One-pot synthesis of beta-amido ketones using Bronsted acidic ionic liquid as an efficient and reusable catalyst

Krishna M. Deshmukh, Ziyauddin S. Qureshi, Nitin S. Nandurkar and Bhalchandra M. Bhanage
Canadian journal of chemistry, Vol.87(2), pp.401-405
01/02/2009
DOI: https://doi.org/10.1139/V08-173

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
An efficient protocol was developed for one-pot condensation of an aldehyde, ketone, acetyl chloride, and nitriles catalyzed by a stable and reusable 1-methyl-imidazolium hydrogen sulfate ([Hmim][HSO4]) as a Bronsted acidic ionic liquid. The system tolerated a variety of functional groups affording the corresponding beta-amido ketones in moderate to good yields under milder operating conditions.

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