Abstract
Readily prepared copper nanoparticles are an effective catalyst for 1,3-dipolar cycloaddition of carbohydrate azide and a variety of alkynes that furnishes the corresponding 1,2,3-triazole-sucrose derivatives in excellent yields. Products were screened for their antimycobacterial activity against
strain. Two compounds,
, demonstrate significant growth inhibitory activity against the bacterial strain with a MIC of 3.125 mg/mL. The presence of an amide group on the 1,2,3-triazole ring enhances the inhibition activity of the molecules. The active compounds are not toxic to a normal cell line which signifies the lack of general cellular toxicity of these compounds.