One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N '-benzyl-N,N-dimethylureas

Keith Smith; Gamal A. El-Hiti; Amany S. Hegazy

doi:10.1039/b926983e

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One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N '-benzyl-N,N-dimethylureas

Journal article

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One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N '-benzyl-N,N-dimethylureas

Keith Smith, Gamal A. El-Hiti and Amany S. Hegazy

Chemical communications (Cambridge, England), Vol.46(16), pp.2790-2792

01/01/2010

DOI: https://doi.org/10.1039/b926983e

PMID: 20369184

Abstract

Chemistry

Chemistry, Multidisciplinary

Physical Sciences

Science & Technology

Lithiation of various N'-benzyl-N,N-dimethylureas with t-BuLi (3.3 mole equivalents) in anhydrous THF at 0 degrees C followed by reactions with various electrophiles afforded the corresponding 3-substituted isoindolin-1-ones in high yields.

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Title: One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N '-benzyl-N,N-dimethylureas
Creators - without role: Keith Smith - Cardiff University
Gamal A. El-Hiti - Cardiff University
Amany S. Hegazy - Cardiff University
Publication Details: Chemical communications (Cambridge, England), Vol.46(16), pp.2790-2792
Publisher: Royal Soc Chemistry
Number of pages: 3
Grant note: Cardiff University
Identifiers: 9948524408331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article