Abstract
New 2-methyl-5-(4-oxo-2-(substituted phenyl)thiazolidin-3-yl)thieno[3,4-
d
]-pyrimidin-4-one, 5-(2,7-diphenyl-5-thioxo-5,6,7,7a-tetrahydrothiazolo[4,5-
d
]pyrimidin-3(2
H
)-yl)-2-methylthieno[3,4-
d
]pyrimidin-4(3
H
)-one, and 2-methyl-5-(5-phenyl-thiazolo[5,4-
d
]isoxazol-6(5
H
)-yl)thieno[3,4-
d
]pyrimidin-4(3
H
)-one have been prepared under microwave-assisted and conventional conditions. The new compounds were screened for their in vitro antimicrobial activity against two gram-positive bacteria (
Bacillus subtilis
NCIM-2063 and
Staphylococcus aureus
NCIM-2901), one Gram-negative bacteria (
Escherichia coli
NCIM-2256), and three fungal strains (
Candida albicans
NCIM-3471,
Aspergillus flavus
NCIM-539, and
Aspergillus niger
NCIM-1196) and showed promising biological activity.