Sign in
Back
Onset of dementia is associated with apolipoprotein E epsilon 4 in Down's syndrome
Journal article   Peer reviewed

Onset of dementia is associated with apolipoprotein E epsilon 4 in Down's syndrome

N Schupf, D Kapell, J H Lee, W Zigman, B Canto, B Tycko and R Mayeux
Annals of neurology, Vol.40(5), pp.799-801
01/11/1996
DOI: https://doi.org/10.1002/ana.410400518
PMID: 8957023

Abstract

Clinical Neurology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Science & Technology
We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of beta-amyloid deposition.

Metrics

1 Record Views

Details