Open Targets: a platform for therapeutic target identification and validation

Gautier Koscielny; Peter An; Denise Carvalho-Silva; Jennifer A. Cham; Luca Fumis; Rippa Gasparyan; Samiul Hasan; Nikiforos Karamanis; Michael Maguire; Eliseo Papa; Andrea Pierleoni; Miguel Pignatelli; Theo Platt; Francis Rowland; Priyanka Wankar; A. Patricia Bento; Tony Burdett; Antonio Fabregat; Simon Forbes; Anna Gaulton; Cristina Yenyxe Gonzalez; Henning Hermjakob; Anne Hersey; Steven Jupe; Senay Kafkas; Maria Keays; Catherine Leroy; Francisco-Javier Lopez; Maria Paula Magarinos; James Malone; Johanna McEntyre; Alfonso Munoz-Pomer Fuentes; Claire O'Donovan; Irene Papatheodorou; Helen Parkinson; Barbara Palka; Justin Paschall; Robert Petryszak; Naruemon Pratanwanich; Sirarat Sarntivijal; Gary Saunders; Konstantinos Sidiropoulos; Thomas Smith; Zbyslaw Sondka; Oliver Stegle; Amy Tang; Edward Turner; Brendan Vaughan; Olga Vrousgou; Xavier Watkins; Maria-Jesus Martin; Philippe Sanseau; Jessica Vamathevan; Ewan Birney; Jeffrey Barrett; Ian Dunham

doi:10.1093/nar/gkw1055

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Open Targets: a platform for therapeutic target identification and validation

Journal article

Open access

Peer reviewed

Open Targets: a platform for therapeutic target identification and validation

Gautier Koscielny, Peter An, Denise Carvalho-Silva, Jennifer A. Cham, Luca Fumis, Rippa Gasparyan, Samiul Hasan, Nikiforos Karamanis, Michael Maguire, Eliseo Papa, …

Nucleic acids research, Vol.45(D1), pp.D985-D994

04/01/2017

DOI: https://doi.org/10.1093/nar/gkw1055

PMCID: PMC5210543

PMID: 27899665

Abstract

Biochemistry & Molecular Biology

Life Sciences & Biomedicine

Science & Technology

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target-and disease-centric workflows. The Open Targets Validation Platform is accessible at https:// www.targetvalidation.org.

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Title: Open Targets: a platform for therapeutic target identification and validation
Creators - without role: Gautier Koscielny - Open Targets
Peter An - Open Targets
Denise Carvalho-Silva - Open Targets
Jennifer A. Cham - Open Targets
Luca Fumis - Open Targets
Rippa Gasparyan - Open Targets
Samiul Hasan - Open Targets
Nikiforos Karamanis - Open Targets
Michael Maguire - Open Targets
Eliseo Papa - Open Targets
Andrea Pierleoni - Open Targets
Miguel Pignatelli - Open Targets
Theo Platt - Open Targets
Francis Rowland - Open Targets
Priyanka Wankar - Open Targets
A. Patricia Bento - Open Targets
Tony Burdett - Open Targets
Antonio Fabregat - Open Targets
Simon Forbes - Wellcome Sanger Institute
Anna Gaulton - Open Targets
Cristina Yenyxe Gonzalez - Open Targets
Henning Hermjakob - Open Targets
Anne Hersey - Open Targets
Steven Jupe - Open Targets
Senay Kafkas - European Bioinformatics Institute
Maria Keays - Open Targets
Catherine Leroy - Open Targets
Francisco-Javier Lopez - Open Targets
Maria Paula Magarinos - Open Targets
James Malone - Open Targets
Johanna McEntyre - Open Targets
Alfonso Munoz-Pomer Fuentes - Open Targets
Claire O'Donovan - Open Targets
Irene Papatheodorou - Open Targets
Helen Parkinson - Open Targets
Barbara Palka - Open Targets
Justin Paschall - Open Targets
Robert Petryszak - Open Targets
Naruemon Pratanwanich - Open Targets
Sirarat Sarntivijal - Open Targets
Gary Saunders - Open Targets
Konstantinos Sidiropoulos - Open Targets
Thomas Smith - Open Targets
Zbyslaw Sondka - Open Targets
Oliver Stegle - European Bioinformatics Institute
Amy Tang - Open Targets
Edward Turner - Open Targets
Brendan Vaughan - Open Targets
Olga Vrousgou - Open Targets
Xavier Watkins - Open Targets
Maria-Jesus Martin - Open Targets
Philippe Sanseau - Open Targets
Jessica Vamathevan - European Bioinformatics Institute
Ewan Birney - Open Targets
Jeffrey Barrett - Open Targets
Ian Dunham - Open Targets
Publication Details: Nucleic acids research, Vol.45(D1), pp.D985-D994
Publisher: Oxford Univ Press
Number of pages: 10
Grant note: open innovation public-private partnership Open Targets
Identifiers: 9944616008331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article