Abstract
A novel momonuclear metal chelates were derived from Zn(II), Pd(II), VO(II) and Cr(III) ions with azomethine (BSQ) [BSQ = 4-Bromo-2-(quinolin-8-yliminomethyl)-phenol] ligand. The prepared compounds were subjected to different analytical and spectroscopic techniques as, IR, (1H) NMR, UV-Vis, molar conductivity, magnetic moment and thermogravimetric analysis (TGA) to elucidate their structures. Accordingly, the most fitted geometry has been suggested for each complex. The ligand acts as a tridentate via NNO donors towards the metal ions inside octahedral geometry with Cr3+, square pyramidal with VO2+, tetrahedral with Zn2+ and square planner with Pd2+ ion. Thermo-kinetic parameters for the complexes have been determined and the values suggest the presence of ordered activated complexes. The reactivity of new compounds towards DNA was examined by different methods and the binding kinds seem to electrostatic, intercalation, or replacement. Also, in-vitro antimicrobial and anticancer potency of the compounds were evaluated. In addition, the therapeutic behavior of the complexes appeared promising towards breast cancer cells (MCF-7) in a concentration-dependent manner. Moreover, the redox potential of the newly synthesized compounds was evaluated and the results reflect suitability of Pd(II) complex in controlling the free radicals. Variable theoretical treatments were performed aiming to confirm the structural formulae as well as the biological assay results. A promising antimicrobial and anticancer behavior was recorded with Pd( II) complex (BSQPd) via in-vitro and insilico ways. (C) 2021 Elsevier B.V. All rights reserved.