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Optimization of conditions for preparing vitamin K-3 by oxidation of 2-methylnaphthalene with chromium trioxide in acid solutions
Journal article   Peer reviewed

Optimization of conditions for preparing vitamin K-3 by oxidation of 2-methylnaphthalene with chromium trioxide in acid solutions

D. V. Eremin and L. A. Petrov
Russian journal of applied chemistry, Vol.82(5), pp.866-870
01/05/2009

Abstract

Chemistry Chemistry, Applied Physical Sciences Science & Technology
Optimal conditions were found for oxidation of 2-methylnaphthalene to 2-methyl-1,4-naphthoquinone with chromium trioxide in sulfuric and acetic acids. The following factors were varied: degree of acid dilution with water, substrate to oxidant weight ratio, and reaction temperature and time. The influence of the rate of reactant mixing and of the reaction temperature on the reaction course was evaluated.

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