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Organocatalytic asymmetric 5-hydroxypyrrolidine synthesis: a highly enantioselective route to 3-substituted proline derivatives
Journal article   Peer reviewed

Organocatalytic asymmetric 5-hydroxypyrrolidine synthesis: a highly enantioselective route to 3-substituted proline derivatives

Ramon Rios, Ismail Ibrahem, Jan Vesely, Henrik Sunden and Armando Cordova
Tetrahedron letters, Vol.48(49), pp.8695-8699
03/12/2007
DOI: https://doi.org/10.1016/j.tetlet.2007.10.028

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
The highly enantioselective organocatalytic tandem reaction between 2-acylaminomalonates and alpha,beta-unsaturated aldehydes is presented. The reaction is a direct entry to 5-hydroxypyrrolidines and 3-substituted proline derivatives, which are furnished in high yields and 90-99% ee. (c) 2007 Elsevier Ltd. All rights reserved.

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