Abstract
The Oro-facial-digital syndrome (OFDS) is a rare developmental anomaly characterized by congenital malformations involving the face, oral cavity, hands and feet. Other organ systems can be involved, defining specific types of OFDS. A recessive mode of inheritance is proposed. To date 13 types have been distinguished based on characteristic clinical manifestations. OFDS has an estimated incidence of 1 in 50,000-250,000 newborns. Two cases of OFDS (15-year-old female and 52-year-old male), who reported to the outpatient clinic of Oral Medicine Department, are presented here. The first case reported with malalignment of teeth and the second one with the complaint of bleeding from the palate since 2 weeks. The overlapping features exhibited by different types of OFDS (as seen in these 2 cases) make the diagnosis extremely difficult. (C) 2014 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.(star)