Abstract
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•Ortho-palladated complexes were synthesized and characterized by different spectroscopic techniques.•The prepared complexes were characterized using IR, 1H n.m.r, mass spectroscopy, molar conductance and X-ray crystallography.•The antibacterial activity was tested against Pseudomonas aeruginosa, Escherichia coli and staphylococcus aurous.•Cytotoxic activity of the compounds was examined against A2780 and HCT-116 cancer cell lines.
Ten newly synthesized ortho-palladated complexes of the type [PdCl(bhq)L] (1–10) (where bhp = benzo[H]quinolate, L = 2-aminobenzothiazole (2-abt), 2-amino-benzimidazole(2-abi), 2-aminothiazole(at), imidazole(im), 2-aminopyridine(2-apy), 2-amino-3-methylpyridine(2-ampy), 2-amino-5-chloropyridine(2-acpy), 3-methyl-pyridine (3-mpy), 2-methylpyridine(2-mpy)or2-pyridinemethaneamine (2-pyma) have been prepared by bridge opening reaction of dimeric [PdCl(bhq)]2 with two equivalent of various aromatic N-donor ligands(L). The prepared complexes were characterized using IR, 1H n.m.r, mass spectroscopy, molar conductance, and X-ray crystallography. The results indicate that all complexes have a neutral square planar shape except complex (10) is ionic have electric conductance (40 µs), then approved by the addition of AgNO3 solution to afford white precipitate of AgCl. The biological activity of the prepared complexes was examined against Pseudomonas aeruginosa, Escherichia coli and staphylococcus aurous. The complexes showed good to moderate activity against the three pathogenic bacteria. Further more complex 4, displays the highest anti-bacterial activity than the other complexes. Some of the synthesized complexes were evaluated as anticancer, screening against A2780 and HCT-116 cell lines using the MTT colorimetric assay. The[Pd(bhq)Cl(im)] (4)complex exhibited significant cytotoxicity against the HCT-116 and A2780 cell lines with IC50 values are 8.67 ± 1.04 µM and 6.32 ± 0.86 µM, respectively.