Abstract
A series of reactions with selenocystamine and its analogous disulfide molecule were carried out in aqueous solutions. It was observed that diselenide was faster reactive to gold(III) compare to its analogous disulfide molecule. The results are compared with similar diselenide and disulfide molecule with other gold(I) drugs. In this paper, we have demonstrated that Au(III) selectively reacts first with diselenide and after complete reactions of diselenide the excess Au(III) reacts with disulfide. This observation is very significant from gold-based drug point of view.
Gold(III) reacts with selenocystamine (diselenide) and immediately breaks the diselenide-bond as observed by
13C NMR spectroscopy. It is also observed that diselenide is more reactive to gold(III) compare to its analogous disulfide (cystamine) molecule. The results are compared with similar diselenide and disulfide molecule with other gold(I) drugs.