Abstract
Two amides, heitziamide A (
1) and heitziamide B (
2) and two phenylethanoids, heitziethanoid A (
3) and heitziethanoid B (
4) were isolated from the stem bark of
Fagara heitzii together with thirteen known compounds. The oxidative burst inhibitory activity and cytotoxicity of some of these compounds are also reported.
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from
F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis.
Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells.
All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC
50
=
2.0–6.5
μM, but no cytotoxic effect was observed (IC
50
>
100
μM).