Abstract
Oxindole derivatives 3-25 have been synthesized from commercially available oxindole by refluxing with different aromatic aldehydes in good yields. Their in vitro antiglycation potential has been evaluated. They showed a varying degree of antiglycation activity with IC50 values ranging between 150.4 - 856.7 mu M. 3-[(3-Chlorophenyl) methylidene]1,3- dihydro-2H-indol-2-one (IC50 = 150.4 +/- 2.5 mu M) is the most active compound among the series, better than the standard rutin with an IC50 value 294.5 +/- 1.50 mu M. The structures of the compounds were elucidated by H-1-NMR and mass spectroscopy and elemental analysis. A limited structure-activity relationship has been developed.