Abstract
Gallbladder carcinoma (GBC) is considered a fatal but seldom occurring cancer of the digestive tract. The process through which a gall bladder adenoma pro-gresses to carcinoma is still unclear. Also, GBCs are seen to appear from pathways comprising metaplasia or dysplasia or from pre-existing adenomas. The only chance of cure is early diagnosis yet despite advances in imaging modalities it seems impossible. Biomarkers are considered an indicator of a biological state. The p53, biomarker lies among rapidly mutated tumor suppressor genes in neoplasms. p53 serves as a scout, which checks for abnormal cell growth against cancer in most of the cells. Proto-oncogenes and the tumor-suppressor genes are considered important factors in the development and prognosis of gallbladder neoplasms. P53 has also been found in gallbladder carcinomas in various studies.